If you continue browsing the site, you agree to the use of cookies on this website. Establish the cause of salivary gland swelling by asking about. An lec of the parotid is a rare salivary gland tumor accounting for less than 1% of all salivary gland tumors. Parotid gland is the most commonly affected among major salivary glands. Lung carcinomas of the salivary gland type are also known as salivary glandtype tumors of the lung sgttls or bronchial gland neoplasms the usual consignation to the group of nonsmall cell lung cancer nsclc may be unfortunate because the clinical behavior of sgttls can be quite different from that of conventional lung cancers 5. There is an increase in the number of ductal profiles within the gland. In these populations, it is usually associated with epsteinbarr virus. This customization is achieved in accordance with existing clinical standards to guarantee a reliable and safe solution. We represent basal cell adenoma of the parotid gland which was located on the deep lobe of the gland with unusual location the. Parotid small cell carcinoma presenting with longterm. Salivary gland tumors represent 3% of all head and neck tumors. A similar tumor type may be found in the tongue, referred to as ectomesenchymal chondromyxoid tumor.
The annual incidence of salivary gland cancers ranges from 0. Some studies have suggested that the dog1 protein may be essential for salivary gland secretion with a possible role in salivary gland tumourigenesis 5, 9. Developmental changes in the parotid salivary gland of. Capsules are generally better developed in tumors of the major glands, whereas those arising in the palate or other minor salivary or seromucinous gland sites are circumscribed but not usually encapsulated.
Doctors classify the subtype of salivary gland tumor by looking at tumor cells under a microscope, called a histologic evaluation. Minor salivary gland tumors msgts are infrequent, accounting for 1015% of all salivary neoplasms, and are fundamentally located in the palate 50%, lips 15%. Epithelialmyoepithelial carcinoma of salivary gland. Tumors of the salivary glands exhibit a wide variety of behavior and are widely diversified histologically. At the tata memorial hospital 3 in bombay the in cidence of salivary gland tumors is 0. The salivary glands are classified as major or minor. Aug 24, 2009 salivary gland neoplasms slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Losito nsbotti gionna fpasquinelli gminenna pbisceglia m clearcell myoepithelial carcinoma of the salivary glands.
Nov 18, 2016 myoepithelial carcinoma is a rare malignant cancerous tumor that usually occurs in the salivary glands in the mouth, but can also occur in skin and soft tissues. Histopathological study of salivary gland tumors 88 int j res med. More recently, dog1 expression has been reported in salivary gland tumours 68, in particular, as a marker for acinic and intercalated duct cells. It is a benign salivary gland tumor that consists entirely of myoepithelial cells with variable cellular morphologies including spindle, epithelioid, plasmacytoid, or clear cells. In this report, we discuss the histologic criteria required to diagnose malignancy in salivary gland myoepithelial tumors. Myoepithelioma is usually a benign tumor arising from neoplastic myoepithelial or basket cells which are found between the basement membrane and the. Primary involvement of the salivary glands in small cell carcinoma is rare, and has one of the worst prognoses of salivary gland neoplasms. Learn vocabulary, terms, and more with flashcards, games, and other study tools. The abundant serous exocrine cells make up the bulk of the gland. Myoepitheliomas are most common in young adults between the ages of 30 and 50. Myoepithelioma is a rare benign tumor of the salivary glands and is usually seen in the parotid gland and the minor salivary glands.
Nov 17, 2014 salivary gland, sublingual, duct hyperplasia in a male f344n rat from a chronic study higher magnification of figure 5. Pdf myoepithelioma of a minor salivary gland of the cheek. The minor salivary glands consist of 800 small mucussecreting glands located throughout the lining of the. The major salivary glands consist of the parotid, submandibular, and sublingual glands. It is observed in a wide age category of children and adults. A final diagnosis of salivary gland myoepithelioma with focal capsular invasion was made, and the case was regarded as a myoepithelial tumor of uncertain malignant potential. In western countries, salivary gland lymphoepitheliallike carcinomas are uncommon and only 14 cases have been described so far. They most commonly affect the major and minor salivary glands with the parotid gland being the most common, approximately 40%.
Salivary gland myoepithelioma with focal capsular invasion. Myoepithelial carcinoma is a rare malignant cancerous tumor that usually occurs in the salivary glands in the mouth, but can also occur in skin and soft tissues. Evaluation of cystic salivary gland lesions by fineneedle aspiration. Presence of a tumor mass on the face or in the mouth. The parotid gland pg is mainly composed of serous acinisecreting. Most of these tumors are located on the parotid region. The cystic structures are filled with mucoid material and necrotic debris. Review of the major and minor salivary glands, part 1. Pdf myoepithelioma of a minor salivary gland of the.
Myoepitheliomas are most common in young adults between the ages of 30 and 50 and there are very few cases reported in. However, it has been reported that some cases have a favorable outcome, although the prognostic factors are still under consideration. The histological appearance includes solid, myxoid and reticular growth patterns. It was once considered to be a type of pleomorphic adenoma pa, but myoepitheliomas are today believed to be relatively aggressive tumors. Although parotid gland constitutes 60% of all pleomorphic adenomas, minor salivary glands constitute only 8% of them 1. Myoepithelioma of salivary gland is an uncommon benign tumor typically arising in the major salivary glands. Judiciously applied, fnab can assist the clinician in developing a suitable treatment plan. Myoepithelioma of the head and neck, also myoepithelioma, is a salivary gland tumour of the head and neck that is usually benign. As the name suggests, it consists of myoepithelial cells. Physiology, pathology and regeneration of salivary glands mdpi. Gonsai3 1resident, 2additional professor, 3professor and head, department of pathology, b.
Myoepithelioma is a rare neoplasm of the salivary glands, generally occurring in the parotid gland and less often in the minor accessory salivary glands of the oral cavity. Lymphoepitheliomalike carcinomas lec of salivary glands represent rare epithelial malignancies, with most cases affecting the parotid gland. Also most of the parotid benign tumors are located on the superficial lobe. Myoepithelioma is a wellcircumscribed or encapsulated tumor. Although surgery has been used for treatment of epithelialmyoepithelial carcinoma at all sites, the present case shows that chemotherapy and radiotherapy may be a viable option for treating epithelialmyoepithelial carcinoma of the base of tongue. Myoepithelioma of the head and neck, also myoepithelioma, is a salivary gland tumour of the head and neck that is usually benign as the name suggests, it consists of myoepithelial cells. A case report of coexistence of a sialolith and an adenoid cystic. Tumors of minor salivary glands e583 introduction salivary gland neoplasms represent less than 1% of all tumors, and 35% of all head and neck neoplasms. Parotid lesions never cause facial nerve dysfunction or cervical lymphadenopathy, and those of the palate rarely ulcerate. It can be present in individuals of a wide age range including children and adults. Case epithelialmyoepithelial carcinoma of the report base.
Lymphoepitheliallike carcinoma of the parotid gland. Tumors of the salivary glands exhibit a wide variety of. This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment. Primary lymphoepitheliomalike carcinoma of minor salivary gland.
Salivary gland tumours are rare and most cases are referred to the head and neck clinic. Additionally, ser156 phosphorylation may be important for cancer development. This report summarizes the experience with tumors of salivarygland origin observed at the massachusetts general hospital from 1930 to 1941, inclusive. Anatomy, head and neck, sublingual gland statpearls ncbi. Pdf spindle cell myoepithelioma of the parotid gland. Fineneedle aspiration biopsy fnab is a useful preoperative technique for the evaluation of patients with a salivary gland lesion1,2. Myoepithelioma me is a benign salivary gland tumor composed almost exclusively of sheets, islands, or cords of cells with myoepitheliomal differentiation.
Clear cell carcinoma of minor salivary gland case report. Salivary glands primary salivary gland neoplasms malignant lymphoepithelial carcinoma. Mar 18, 2015 myoepithelioma was recognized as a histologically distinct entity by the world health organization who in 1991. Salivary gland tumors tehran university of medical sciences. Mar 27, 2018 myoepithelioma of salivary gland is an uncommon benign tumor typically arising in the major salivary glands. Salivary gland hyperplasia nonneoplastic lesion atlas. Characterisation of dog1 expression in salivary gland. Primary lymphoepitheliomalike carcinoma of minor salivary. The majority of these neoplasms are benign and only 20% are malignant.
Your doctor can provide more information about your specific diagnosis. A comparative study of mucin histochemistry in mucous cells of salivary glands and odontogenic cysts ridwaana carim a research report submitted to the faculty of health sciences, school of oral health sciences, university of witwatersrand, south africa, in partial fulfilment of the requirements for the degree of. The signs and symptoms of myoepithelioma of salivary gland may include. Clinically, an etiological classification of sialadenitis is mandatory. Lymphoepithelial carcinoma is a rare salivary gland lesion. Salivary gland tumours or neoplasms are tumours that form in the tissues of salivary glands. Parotid gland the parotid gland is composed mainly of serous cells and produces saliva that is watery and rich in enzymes amylase and lysozyme and antibodies. Myoepitheliomas usually occur in the major salivary glands and appear in the subcutis of the ventral neck. The tumor is composed exclusively of myoepithelial cells that show spindle, plasmacytoid, and clear cell morphology. Discussion salivary gland tumors are complex neoplasms which account for 3% of all head and neck tumours.
Classification of the pathology of diseases of the salivary glands. Myoepithelioma is usually a benign tumor arising from neoplastic myoepithelial or basket cells which are found between the basement. The salivary glands in mammals are exocrine glands that produce saliva through a system of ducts. They are seen as reddishyellow masses, which may be solid or a mixture of solid and cystic. A myoepithelioma neoplasm is almost entirely composed of myoepithelial cells and is most frequently located in the parotid gland and in the minor salivary glands of the hard palate. Vimentin and s100 protein are very sensitive but nonspecific immunohistochemical markers of neoplastic myoepithelium. Nonneoplastic disorders of the salivary glands are divided into the following groups. Pleomorphic adenoma a salivary gland tumor as nasal mass.
The sublingual gland is the smallest of the three major salivary glands, which also include the parotid and submandibular glands. The most common locations of myoepithelioma of the head and neck are the parotid gland and the palate. Plasmacytoid myoepithelioma of minor salivary glands. Humans have three paired major salivary glands parotid. Dec 12, 2011 myoepithelioma is a rare benign tumor of the salivary glands and is usually seen in the parotid gland and the minor salivary glands. The majority of these neoplasms are benign 80% and only 20% are malignant. The parotid salivary gland being one of the major salivary glands of. Only 1% of all salivary gland neoplasms are myoepitheliomas. Approximately 66% of these tumors occur in a part of the salivary gland, known as the parotid gland. Sialoliths are hard formations, with round or oval shape and a variety of sizes. Epithelialmyoepithelial carcinoma emc of salivary gland is a malignant epithelial tumor, composed of two distinct cell types, affecting either the major or minor salivary glands. Original article histopathological study of salivary gland. Myoepithelioma, salivary glands, mouse springerlink.
Multidisciplinary therapy was usually required to achieve longterm survival. These glands have an important role in aliments digestion through their secretions saliva. Although clear cells are found in a number of salivary gland tumours, most can be excluded based on other typical cellular or growth phenotypes. Lung carcinomas of the salivary gland type radiology. Sep 10, 2018 epithelialmyoepithelial carcinoma emc of salivary gland is a malignant epithelial tumor, composed of two distinct cell types, affecting either the major or minor salivary glands. Case epithelialmyoepithelial carcinoma of the report base of. Myoepithelioma is a rare neoplasm of the salivary glands, generally occurring in the parotid gland and less often in the minor accessory salivary gland of the oral cavity. You will find a list of common subtypes of salivary gland tumors. As reaffirmed in our case, lec is more common in women, occurs primarily in the parotid gland, and has an ethnic predilection. Pleomorphic adenoma is the most common benign salivary gland tumor. The minor salivary glands consist of 800 small mucussecreting glands located throughout the lining of the oral cavity. Among these 8590% originates from the major salivary glands.
Salivary gland, sublingual, duct hyperplasia in a male f344n rat from a chronic study higher magnification of figure 5. Primary lymphoepitheliallike carcinoma of the parotid gland is a rare tumour with an increased incidence among eskimos and orientals. To our knowledge, there was only one lec arising from the minor salivary gland described in the englishlanguage literature. Classically, they are found in the parotid gland or palate. Most 70% salivary gland tumors originate in the parotid gland, with the bulk of the remainder arising in the submandibular gland 8% and in the minor salivary glands 22%. Surgical management of salivary gland tumors aliu sanni md long island college hospital. Twelve of these were located within the parotid gland and the submandibular gland and intraoral minor salivary glands accounted for five each. One duct is dilated and has an increased number of epithelial cells arrow.